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10.1152/ajpgi.00048.2015 63

Nrf2 can bind to AREs on PINK1 promoter, and then upregulate PINK1 expression and promote mitophagy (Murata et al., 2015

We confirm that this manuscript is original, has not been published previously, and is not under consideration elsewhere

While this may come as a surprise that your body maintains itself via adult stem cells living in tissue, thats how it works

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People with Absorption Issues Several conditions can impair B12 absorption: Pernicious anaemia An autoimmune condition thats the most common cause of severe B12 deficiency in the UK Crohns disease or coeliac disease Previous gastric surgery Including gastric bypass Chronic use of certain medications Including proton pump inhibitors (PPIs), metformin, and some anti-seizure medications Others at Risk Pregnant and breastfeeding women (who have increased B12 requirements) Heavy alcohol consumers Those with chronic inflammation affecting gut health People taking certain oral contraceptives B12 Deficiency in the UK: How Common Is It