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In SHR rats, BBR was shown to be able to inhibit cholinesterase and decrease BP by directly bonding the M receptor of vascular endothelial cells without dilating the blood vessels (113)

Fournier M, Monin A, Ferrari C, Baumann PS, Conus P, Do K

With regard to measure reporting, we estimate the removal of this measure will decrease burden for voluntary reporting for the CY 2025 reporting period by 383 hours (4,590 ASCs 50 percent of ASCs 0.167 hours per ASC) at a savings of $21,088 (383 hours $55.06/hour) and 765 hours annually (0.167 hours 4,590 ASCs) at a savings of $42,121 (765 hours $55.06/hour) for mandatory reporting beginning with the CY 2026 reporting period

Supplementation through the injection addresses this gap proactively rather than waiting for deficiency symptoms to appear

By preventing contamination, it protects the water for longer use

Only increase if lower doses plateau and you tolerate well