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Lee, Molecular and Cellular Biology, DOI: 10.1158/1538-7445.AM2020-1239 Published August 2020

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This effect was blocked by specific D4-inhibition with L-745,870 and confirmed in Drd4 / mice, which showed profound age-dependent reduction in T h 2 inflammation with altered allergen exposure response in the lung of neonatal animals (Wang, Cohen et al., 2019)

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While ART reduces these effects, treated individuals still show substantial pathology in dopamine-rich regions including striatal dysfunction, increased myeloid activation, the accumulation of infected myeloid cells, and neuronal dysfunction (Anthony et al., 2005