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A recent meta-analysis performed on patients with T2DM showed that all GLP-1 dose groups had a significantly higher incidence of vomiting compared to both placebo and conventional therapy, especially in individuals treated with exenatide [51]

10.1166/jbn.2017.2474 53 HaoY.LiH.CaoY.ChenY.LeiM.ZhangT.et al (2019)

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In trials, the most significant weight loss tends to happen earlier in treatment, with meaningful drops in body weight during the first several months