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These interactions may contribute to improved sleep architecture and reduced stress signaling in experimental conditions

Meanwhile, exenatide, another GLP-1 agonist approved for obesity treatment, showed a higher reduction in body weight when lifestyle modifications were adopted (Rosenstock et al., 2010)

Additionally, besides increased hemoconcentration and decreased hepatic blood flow (which negatively influences Tac metabolism), intestinal damage and inflammation could lead to increased drug permeability and negatively affect CYP3A and P-gp expression, particularly in the lower intestine (49, 50)

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As a GIP receptor agonist, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycemia