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Sullivan DM, Wehr NB, Fergusson MM, Levine RL, Finkel T

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10 A note on estradiol vs estriol vs conjugated equine estrogens Though estradiol is the predominant estrogen used for control of vasomotor symptoms in menopausal and postmenopausal women it is sometimes used in combination with other estrogens such as estriol or conjugated equine estrogen products, such as Premarin, are sometimes used in place of estradiol

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However, some researchers argue that short peptides like EpitalON may retain activity when taken orally