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1, 28, 29, 30, 31, 32 Especially during early life, traumatic stress may result in lifelong programming, potentially through methylation-mediated alterations in expression of genes implicated in MDD

For persistent constipation beyond 3-4 weeks, providers may prescribe agents that enhance intestinal secretionsuch as linaclotide or lubiprostonewhich directly counteract GLP-1's motility-slowing effect

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