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10.1016/0039-9140(66)80244-8 Talanta 87 SzaboC

Micro-environment and intracellular metabolism modulation of adipose tissue macrophage polarization in relation to chronic inflammatory diseases

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M1 secretes pro-inflammatory cytokines (mainly IL-1, IL-6, and TNF), which lead to osteoclast (OC) activation and joint erosion, and M2 produces anti-inflammatory cytokines such as IL-10 and transforming growth factor- (TGF-) to promote angiogenesis and tissue remodeling [82, 83]

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