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Importantly, the current evidence supporting this approach is largely indirect and derived from studies conducted in patients with established PsO and metabolic comorbidities, rather than in well-characterized early PsA cohorts.An additional and largely underexplored aspect concerns the safety of combining GLP-1RAs with bDMARDs

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The pathogenesis of DKD involves a complex interplay of metabolic, hemodynamic, inflammatory, oxidative, and fibrotic pathways

GLP-1 medications can cause side effects ranging from mild nausea to severe complications like pancreatitis or kidney problems

Data are mean SEM from chow-fed WT (vehicle or drug treated) and Bbs5 / (vehicle or drug treated) male mice