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The once widely accepted primary role for -amyloid in sporadic AD (known as the amyloid cascade hypothesis) is currently criticised as not being the sole cause of AD, but nevertheless, amyloid accumulation is clearly a part of AD pathology and evokes multifaceted glial responses

Additionally, metformin has been shown to be effective in reducing pregnancy-related complications in patients with PCOS, including gestational diabetes, hypertension, and preeclampsia

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Analytical Distinction: Total vial mass, individual-component quantity, chromatographic composition, molecular identity, copper content, peptide integrity and analytical recovery are separate properties