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6-(n-benzoylamino)purine as a novel and potent inhibitor of xanthine oxidase: inhibition mechanism and molecular modeling studies

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MC-derived histamine drives severity of experimental colitis at least in part by recruiting neutrophils into the colonic mucosa To next determine whether histamine, the ligand for H4R, was also required for neutrophil infiltration into the colon after Ox-induced colitis, we examined Ox-induced colitis in histamine-deficient HDC / and WT mice and found that HDC / mice exhibited less severe colitis with significantly reduced weight loss, disease activity index scores, and histology scores (Figure 4ac), similar to H4R / mice

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