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J Neurol Sci 55(1):99115 Nihei K, McKee AC, Kowall NW (1993) Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients

Impaired Glutathione Recycling in Dementia As shown by Irene Martinez de Toda et al 2019 (8) data, patients with dementia have a reduction in both the enzymes (GR and GP) that recycle glutathione

M., Nofziger, C., Dossena, S., Paulmichl, M

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showed that malonate prolonged the proliferation window of cardiomyocytes in neonatal mice and reintroduced cardiomyocytes into the cell cycle in adult injured hearts by inhibiting succinate dehydrogenase (SDH) in the tricarboxylic acid cycle (80)

In such cases, tirzepatide continuation poses no additional safety risk