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Clinical Data on Tesofensine for Weight Loss Tesofensines weight loss potential was first demonstrated in a landmark 24-week randomized, double-blind, placebo-controlled trial published in The Lancet a study that quickly set it apart from other anti-obesity compounds

doi: 10.3389/fphar.2025.1551062 Received 24 December 2024 Accepted 04 April 2025 Published 02 June 2025 Volume 16 - 2025 Edited by Yasmina Mohammed Abd-Elhakim, Zagazig University, Egypt Reviewed by Amany Abdel-Rahman Mohamed, Zagazig University, Egypt Ozlem Demirel, Baheehir University, Trkiye Updates Copyright 2025 Azzam, Anwar, Abd El-Slam, Diab, Ibrahim, Yousef, Sabry, Darwish, Kaliyamoorthy, Salem and Elsanhory

These findings are encouraging as they indicate that GLP-1 RAs can intervene in one of the root causes of PD neurodegeneration

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However, how and if predicted differences in dynamics of receptor G protein interactions correlate to the differences in the effect of the allosteric coupling of the G protein on TMD binding sites, or the rates of G protein activation are unclear and additional studies will be required to address this