"Just as recent genetic research is helping explain why about 10% of GLP-1 users don't lose weight, there are likely genetic and epigenetic factors that contribute to wide variation in how these treatments affect people psychologically." Even so, Abdullah says he keeps a closer eye on patients with certain risk factors, including: A history of major depressive disorder, anxiety, ADHD or an eating disorder A history of binge eating or using food to cope with stress or emotions A history of responding strongly to antidepressants or stimulant medications Rapid weight loss or inadequate caloric intake Major life stressors or significant life transitions happening at the same time What to do if you notice mood changes on Ozempic or another GLP-1 If you're feeling off on Ozempic or another GLP-1 drug, don't stop the medication abruptly on your own
Evidence-Based Alternatives to Boost Your Metabolism Rather than relying on supplements of uncertain safety and efficacy, there are several evidence-based lifestyle interventions that can support healthy metabolic function without the associated risks
Seek urgent medical attention (call 111, 999, or go to A&E as appropriate) if you experience severe, persistent abdominal pain (which may radiate to your back and could indicate pancreatitis) or signs of dehydration from persistent vomiting
For those interested in optimizing energy without sacrificing muscle mass, combining a mild metabolic enhancer like 5-amino-1mq with MOTS-c can further amplify natural mitochondrial pathways, avoiding the dramatic appetite suppression associated with GLP-1 therapy
Around age 45, our glutathione levels start slipping
Marisa Garshick, a dermatologist based in New York City
