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43 Similarly, semaglutide (0.5 or 1 mg once weekly) over two years in people with type 2 diabetes resulted in a 36% reduction in the progression of nephropathy compared with placebo

Human studies are mixed, though some analyses saw significant weight loss, particularly among obese or older adults, while others saw none

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Quantitative aspects

The primary outcomes were time to the first occurrence of MACE, heart failure composite, cardiovascular mortality, and all-cause mortality

The FDA-approved labeling for liraglutide does not list bupropion as a contraindicated co-medication [1]