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mice with a combination of A and NFT pathology (3xTgAD)

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Also, another oxidant, hydrogen sulfide (H 2 S), was effective against mitochondrial dysfunction in SOD1 G93A mice by increasing the levels of Ca 2+ and inhibiting SOD1 aggregation (Pratt et al., 2012

Implementing the aging effect in our model in a fully data-driven way would require data on neuron- and astrocyte-specific proteomics, metabolomics, and enzyme kinetics