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Of the 350/395 attacks that achieved complete attack resolution (none on the PGI-Severity [PGI-S]) by 24 h, 98.3% had durable effects and no evidence of symptoms reoccurring

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In the SURMOUNT-4 trial published in the New England Journal of Medicine, participants who switched from tirzepatide to placebo regained approximately two-thirds of their lost weight over the subsequent 52 weeks, while those continuing treatment maintained their weight loss and achieved additional reductions

This was followed by another temporary cessation of semaglutide treatment due to unavailability of the drug