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The SUSTAIN-6 trial demonstrated that semaglutide reduces the risk of major adverse cardiovascular events (heart attack, stroke, cardiovascular death) by 26% compared to placebo in patients with type 2 diabetes

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The treatment of T2D has shifted from a gluco-centric approach to a broader cardio-renal-metabolic strategy, emphasizing the prevention of cardiovascular and renal events and the improvement of metabolic aspects beyond glucose control such as promoting weight loss