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Clinical studies Compared with the considerable amount of pre-clinical and mechanistic research reported above, we identified few clinical studies of GLP-1RAs for substance-use disorders (Table 2): three for alcohol 111,112,113 , one for cannabis 114 , two for cocaine 115,116 and two for nicotine 117,118 , while no article about opiates or amphetamines was retrieved

Others see minimal cosmetic change

An unusual feature reported in the literature is timing: in some studies, DSIP given during the day was associated with improved sleep that night , rather than acting as an immediate, bedtime sedative

Leaky gut restoration typically shows gradual improvement over 6-12 weeks as intestinal barrier function strengthens

Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system

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