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During titration, 0.25 mg is a stepping stone

Six-week-old male C57BL/6 mice and adult male Wistar rats (240260 g) were purchased from the Experimental Animal Center of the Shanxi Provincial Peoples Hospital (Taiyuan, China)

That is not an outlier result from a handful of participants

Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, 19117, Al-Salt, Jordan

Mark Greenwald, Professor and Director of the Substance Addiction Research Division at Wayne State University and lead author of the study

Failure to comply with FDA requirements can result in a prescription drug being deemed misbranded under the FDCA