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In certain embodiments, the otic formulations or compositions described herein are formulated to be isotonic with the endolymph and/or the perilymph

For GHK-Cu specifically, the logic is sound even without direct evidence: cumulative copper exposure is lower with reduced frequency, and the gene expression changes initiated during loading persist during maintenance

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Luminescent signal measured in each well was expressed as % of signal elicited by 50 nM dostarlimab in the same plate and the mean of results obtained in 3 independent plates was calculated