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Linarine markedly suppressed the release of inflammatory cytokines, including IL-1 and TNF-, in HCECs, along with regulated the levels of the purinergic receptor [77]
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Data are representative of minimum three independent experiments and the number of biological replicates is quoted in the figure legends
The results demonstrated a significant reduction in this ratio upon HC and CCCP administration, indicating mitochondrial depolarization (Figures 7B,C)
Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production
(2) Xu B, Yang M, Li Z, Zhang Y, Jiang Z, Guan S, Jiang D
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