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Twice weekly dosing reduces peak concentrations by approximately 28% and brings the peak-to-trough ratio down to 2.1

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Analysis of FAERS data from 2003 to 2024 showed significant associations between diabetic retinopathy and semaglutide (PRR, 19.43), dulaglutide (PRR, 9.01), and liraglutide (PRR, 4.4) [95]