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In: Williams Textbook of Endocrinology

High), while albiglutide 50 mg showed no significant effect

Nonetheless, low IGF-1 circulating levels are also associated with reduced insulin sensitivity [207], glucose intolerance, and T2D [207, 208, 214]

[3] In contrast, certain antidepressants may worsen glycaemic control

When to Consider Switching to a Dual-Compound or Alternative GLP-1 Therapy If plateau strategies don't produce results within 6 to 8 weeks, or if you've already optimized your dose with your provider, switching to a different compound may be beneficial