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Injectable GLP-1 agonists are currently accessible to only a small fraction of this population, concentrated in high-income countries with strong pharmaceutical supply chains and insurance systems

This tri-agonist mechanism distinguishes it from currently approved agents such as semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro), which act on one or two of these pathways respectively

One new near-term risk to growth could be inflationary pressures, since a large percentage of GLP-1 sales are driven by out-of-pocket payments, Flynn says

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9 , e013827 (2020)