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In normoglycemic, non-obese rabbits , liraglutide significantly inhibited atherosclerosis progression, with meaningful reductions in percent atheroma volume, plaque macrophage content, cathepsin activity, and systemic CRP

Additionally, the duration of administration can influence outcomes, with some benefits only emerging after prolonged use [258]

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While this is generally not clinically significant, patients on multiple blood pressure medications should be monitored for hypotension, particularly if initiating magnesium supplementation alongside GLP-1 therapy, which may also contribute to modest blood pressure reductions through weight loss

GLP-1 medications produce overall fat loss through caloric deficit driven by appetite suppression, which reduces both subcutaneous and visceral fat proportionally