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The 13 amino acid N-terminal extension further adds to the peptides shelf life and resistance to breakdown, and this 13-amino acid extension results in a dramatically extended half-life of about 20-30 hours compared to the mere minutes of native IGF-1

J Biol Chem (1997) 272(28):17694702.10.1074/jbc.272.28.17694 140 StofegaMRHerringtonJBillestrupNCarter-SuC

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As part of this ongoing research, Huang et al