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In addition, a variant with insufficient evidence to determine its role in disease (N426K) displayed similar results to the benign variants, suggesting that N426K induces no significant enzyme deficiency

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Within mammalian cells, numerous kinases are expressed in G1-phase mitotic cells, including the complexes Cdk4/cyclin-D, Cdk6/cyclin-D, Cdk2/cyclin-E, Cdk2/cyclin A, and Cdk1/cyclin A, which play key roles in progressing the cells from phase G1 to phase S