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In addition, ex vivo assessment of the ability of pancreatic islets to secrete insulin in response to glucose stimulation demonstrated that semaglutide potentiates insulin secretion from isolated islets from LPD but not CD animals (Figure 1I)

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A holistic and systematic approach to pathophysiology could shift models of disease in medicine away from simple associations rooted in empirical reductionism toward an appreciation of network-based models (42)

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