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this theory warrants further study, he says

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Pini LA, Vitale G, Ottani A, Sandrini M

Thus, we speculate that the effects of the RGKT deletion on the stability of the D2 domain, and/or the SCF MAX2 receptorsubstrate complex are too subtle to produce strong effects in vitro, but reduce the longevity and selectivity of the complex sufficiently to decrease ubiquitination efficacy in planta

Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis