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This altered geometry changes the distance and angle of the hydrogen bond with residue R752 to favor the AR LBD interaction with DHT over that with testosterone 68

The amplification was performed by using TaqMan gene expression assays (Hs00167309, Hs00156308, Hs01110250, Hs00195591, Hs01566408, Hs04989912, Hs00958111, Hs04189111, Hs00426835, and Hs99999905) according to the manufacturers instructions

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doi: 10.2147/JIR.S275595 6 Sharifi-RadMv.AKNZuccaPVaroniEMDiniLPanzariniEet al