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Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency
& Gregersen, M
The value of plants used in traditional medicine for drug discovery
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Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice
3ac show that HFD-induced macrophage infiltration, as evidenced by increased mRNA levels of macrophage specific marker genes Cd68, F4/80, and Cd11c, by ~33.2, 22.3-, and 40.6-fold, respectively, over that of control animals fed regular chow
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