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In a rat model of DOCA-salt hypertension, vascular mitochondrial ROS production was markedly elevated, accompanied by the activation of other ROS sources

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Patients in the treatment group (n = 8) were administered intravenous ALA (1200 mg/day) for 7 days in addition to standard medical care, while patients in the control group (n = 9) were treated with saline infusion in addition to standard medical care for 7 days