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The most compelling pathway is through the gut-skin axis

GLP-1 receptors are present not only in the pancreas and gastrointestinal tract but also in the central nervous system , including areas involved in taste perception and appetite regulation

Clinically, this case underscores the necessity of strict adherence to semaglutide titration protocols, such as restarting at 0.25 mg per week and escalating slowly, to minimize gastrointestinal adverse effects [16]

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Additionally, there is a study investigating the role of glyburide in the treatment of PHE in ICH (GATE-ICH, NCT03741530)

And all benefit from consistent, proper refrigeration