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Takahashi-Kanemitsu A, Lu M, Knight CT, Yamamoto T, Hayashi T, Mii Y, et al

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Once acetaminophen metabolizes in the liver by conjugation with glucuronic acid (4067%), sulfuric acid (2046%), and p -aminophenol, it easily crosses the blood-brain barrier and is converted to AM404 ( N -hydroxylation in the liver with the involvement of cytochrome P450 enzymes (especially CYP2E1) to form the toxic metabolite, NAPQI ( N -acetylcysteine must be ingested as soon as possible

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