The answer, based on the molecular biology of the compound and the consistent IGF-1 data we see in clinical practice, is no
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[ [PMID: 25315856] [131] Gleixner, A.M
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Consequently, dual GLP-1/glucagon agonists survodutide, and triple GLP-1/GIP/glucagon agonists retatrutide are not spared gastrointestinal adverse events, as glucagon related pro-emetic signaling may offset any potential tolerability benefits from GIP agonism ( The contribution of amylin-based therapies to gastrointestinal adverse events remains less clear
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