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These results suggest that bTNF- induces a metabolic change in bFLS, shifting from OXPHOS to aerobic glycolysis, with an increase in lactate levels, which could contribute in part to the inflammatory effect mediated by bTNF-

For instance, doxorubicin, a topoisomerase inhibitor, induces DNA damage in cancer cells by interfering with topoisomerases and unwinding supercoiled DNA 24