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The transition from episodic to chronic migraine involves changes in nociceptive thresholds and central sensitization, driven by factors such as high frequency of migraine attacks, overuse of acute medications, obesity, stress, female sex, psychiatric conditions, and low socioeconomic status (34)

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1 Introduction Chronic Obstructive Pulmonary Disease (COPD) constitutes a prevalent chronic respiratory disorder, characterized by persistent respiratory symptoms and airflow obstruction