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The only human study of BPC-157s effects is small and lacks comparison to a placebo

Using this fasting and refeeding paradigm, we next investigated the relative importance of lipid mobilization and restoration in fasting-induced longevity

Both are valid protocols

On the evidence question: The absence of Phase III human trial data for compounds like BPC-157 and TB-500 is a genuine clinical limitation, not a technicality

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In summary, the development of pharmacological agents that promote itaconate production could potentially mitigate pathological inflammatory responses and prevent severe lung injury associated with TB progression