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These methods involve the use of mitochondrially-targeted compounds (e.g., oligomycin, FCCP) in conjunction with the measurement of oxygen consumption rate to assess mitochondrial respiration parameters (Seahorse XFp analyzer technology) [39, 62, 63], as well as high-resolution respirometry to evaluate mitochondrial oxidative phosphorylation (OXPHOS) capacity with complex I + II-linked substrates (Oroboros O2k-technology) [42]

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variations in the cohesion index are significantly correlated with the distribution of functional modules

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Understanding how NRF2 coordinates different metabolic pathways to support cellular detoxification opens new avenues for therapeutic intervention

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