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Postmarketing Experience The following additional adverse reactions have been identified during post approval use

The COX6A and COX7A genes encode tissue-specific isoforms (COX6A1 and COX6A2

Anorexiants are used as a treatment for weight loss, along with a regular plan of diet and exercise

For many people, liver disease is driven by obesity or type 2 diabetes

2024;390 Nauck MA, Meier JJ

Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023