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If Youre Experiencing Strong Side Effects Consider staying at a lower dose longer before increasing to give your body more time to adjust

Bioavailability far exceeds topical application, with the peptide reaching all tissues including those unreachable from surface application

Research demonstrates that therapeutic effects on sexual desire occur primarily through MC4R and MC3R agonism

Response: We appreciate the commenters' input and support for the proposed APC assignment

Cell culture The human ovarian granulosa cell line KGN (Procell, Wuhan, China) was cultured in Dulbecco's modified Eagle's medium (DMEM)-F12 medium (GIBCO-BRL, Invitrogen) containing 10% fetal bovine serum (Invitrogen) and 1% penicillinstreptomycin (Invitrogen) at 37C under 5% CO