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As illustrated in Figure 2, pooled analyses of cardiovascular outcome trials have demonstrated that GLP-1 RAs reduce major adverse cardiovascular events (MACEs) by 14% (HR = 0.86, 95% CI 0.790.94) in patients with type 2 diabetes, with additional significant benefits including 13% reduction in cardiovascular death, 16% reduction in nonfatal stroke, and 10% reduction in hospitalization for heart failure [85]

donors rigorously screened beyond blood standards Rich biologic cocktail MSCs (medicinal signaling cells), growth factors (FGF, PDGF, TGF- family), anti-inflammatory cytokines (IL-10, IL-1Ra), hyaluronic acid (HA), mRNA blueprints, exosomes, amino acids, peptides, carbohydrates Perinatal secretomes and menstrual stem cell-based secretomes (MenSCs): The endometriums antifibrotic program Monthly sterile inflammation, hypoxia, ECM breakdown, and re-epithelialization without scar formationan intrinsic antifibrotic blueprint Mechanistic insights (Cuenca et al., 2018

Modulating the cGASSTING axis is now being explored as a potential therapeutic strategy to slow AD progression