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Plant Cell 10(2):267282 Lueder DV, Phillips MA (1996) Characterization of Trypanosoma brucei -glutamylcysteine synthetase, an essential enzyme in the biosynthesis of trypanothione

A defined off-period lets receptor density and sensitivity recover so the next cycle starts from a fresh baseline rather than a blunted one

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Final classification depends on the committee's recommendation and the FDA's subsequent rulemaking