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Numerous studies have demonstrated that HO-1 has a significant effect on diabetic complications, with induction of HO-1 protein expression enhancing antioxidant defense and reducing inflammatory factors (Table 2)

This protective shell acts as a biological "Trojan Horse," shielding the fragile antioxidant from digestive enzymes and stomach acid as it travels through the gastrointestinal tract

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It plays a key role in neutralizing free radicals and supporting the immune system

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The authors acknowledge the support of the Open Access Publication Fund of the University of Duisburg-Essen