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While the VPA-induced ASD model effectively recapitulates neurodevelopmental and gastrointestinal phenotypes associated with prenatal environmental insults [43], we acknowledge it does not fully represent the genetic heterogeneity of human ASD

This work was supported by the JSPS KAKENHI (JP17H03674, JP21H05047, JP20KK0341, JP20H03252, JP24H01286, and JP24K02024) (S.S.), JST CREST (JPMJCR1863 and JPMJCR24B3) (S.S.), JST CREST (JPMJCR24B3) (T.I.), JST CREST (JPMJCR24B3) (K.G.N.S.), Uehara Memorial Foundation (S.S.), Takeda Science Foundation (S.S.), the National Institute of Health (R35GM149329) (T.I.), the National Science Foundation (000819255) (T.I.), JST FOREST Program (JPMJFR2413) (T.N.), JSPS KAKENHI (JP17K07427, JP20K06625 and JP23H02476) (T.N.), and 2021 NAIST University Fellowships for the Creation of Innovation in Science and Technology (T.F.)

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