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The use of natural, biocompatible exosomes as the delivery vehicle would mitigate many of the toxicity and immunogenicity concerns associated with synthetic nanoparticles, potentially making this a safer and more effective therapeutic strategy [35]

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However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus

Hyperglycemia increases the production of Amyloid Beta-peptide leading to decreased endothelial tight junction

They share the fundamental limitation of symptom management without addressing underlying dysfunction

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