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doi: 10.3389/fendo.2013.00006 Received 15 December 2012 Accepted 16 January 2013 Published 04 February 2013 Volume 4 - 2013 Edited by Anastassios Philippou, National and Kapodistrian University of Athens, Greece Reviewed by Encarnacin Capilla, University of Barcelona, Spain

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These findings strongly support our hypothesis that NAM pretreatment enhances mitochondrial function, likely by improving ETC performance by increasing NAD + levels

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A loading phase will get an individual to their muscular creatine saturation point faster than a consistent daily dose, but isnt necessary unless time to benefit is a critical factor, says OGrady