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10.1001/jamanetworkopen.2020.37341 105 WangM.PuD.ZhaoY.ChenJ.ZhuS.LuA.et al (2020a)

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Peak GH Secretion Occurs During Puberty In Tanner stage III, IV, GH pulse amplitude peaks, driven by estrogen (in both sexes) acting at the hypothalamus to increase GHRH secretion and at the pituitary to enhance GH release per pulse [5]