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Competitive inhibition studies using either an excess of free hemeHPX ligands or with holo-human Tf prevented the binding of TfR1 (both monomer and dimer) to HPX, demonstrating the specificity of the interaction between these two proteins (Figure 1D)

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This psychological pairing makes the injection feel automatic rather than burdensome, significantly improving long-term adherence

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The combination of TMERS and TMB allows for clear and accurate MIBC patient stratification, with patients with high TMB/low TMERS having the best prognosis and those with low TMB/high TMERS having the worst prognosis